BioGenes Has Developed Cellmid’s Midkine Blood Test and Reports Manufacture of First Kits


Berlin, Germany, November 16, 2010 / b3c newswire / - BioGenes GmbH, a supplier of GMP compliant immunoassay and antibody services, has developed and optimized the first ever fully validated ELISA protocol for Midkine detection in blood serum. Furthermore, BioGenes has completed the manufacture of the first batch of MK ELISA kits. Midkine blood test (MK ELISA) has been recently launched by Sydney-based Cellmid Limited (ASX: CDY).
The kits are available for purchase to the global research market directly through Cellmid ( who is now applying for CE marking of its test.


MK ELISA is a highly sensitive and robust assay for the accurate measurement of Midkine in blood serum. Midkine, which is also known as neurite growth-promoting factor 2 (NEGF2), is an embryonic cytokine and well known cancer biomarker that has been found to correlate with cancer progression and malignancy. Midkine shows limited expression in healthy adults, but is detectable in high quantities in the blood and urine of patients with a wide variety of cancers. Cellmid’s MK ELISA kit is therefore suitable for diagnostic development and the validation of cancer diagnostic and prognostic applications.


“Midkine blood test is highly sensitive with a detection limit of 8pg/ml which is well within the range of healthy serum MK levels of 0 to 300pg/ml. The test is also highly selective and shows no cross-reactivity with closely related protein Pleiotrophin. The assay recognizes all major species of Midkine including human, mouse, dog and pig making it highly suitable for animal studies and veterinary cancer diagnostic applications,” says Dagmar Schwertner, Director Marketing at BioGenes.


“I would like to thank BioGenes for their superb technical contribution to this difficult assay development project” said CEO of Cellmid, Maria Halasz. “Their professional and persistent approach has been instrumental in the program’s success” she added.




Midkine ELISA kit: Highly specific with no cross-reactivity to Pleiotrophin or

other serum components

(For a high resolution picture right click and select "Save target as...)




About BioGenes GmbH -

BioGenes is the leading expert in the development of customised solutions for complex antibody and immunoassays projects required by the biopharmaceutical industry. BioGenes GmbH specialises in highly sophisticated antibody and immunoassay development and has successfully developed and produced monoclonal antibodies against a range of antigens of various types. The Company’s clients and partners are from large to small biotechnology companies worldwide and include 8 of the world largest pharmaceutical companies.


About Cellmid Limited (ASX: CDY) -

Cellmid Limited is a biotechnology company listed on the Australian Stock Exchange. The Company is the owner of the most comprehensive intellectual property portfolio around midkine globally. Midkine is a significant novel therapeutic and diagnostic target. It is a native protein expressed during early cancer formation as well as at the onset of a number of inflammatory processes. Cellmid is committed to the commercialisation of its portfolio of therapeutic and diagnostic products.




Dagmar Schwertner

Marketing Director

BioGenes GmbH

Tel. +49-30-65762380

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Media contact

Dr. Sabine Duntze

b3c communications

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