Trifunctional Antibody Catumaxomab Triggers Vaccination Effect Against Cancer
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|Monday, 06 June 2011 08:00 (UTC + 2)|
Munich, Germany, June 6, 2011 / B3C newswire / – TRION Pharma GmbH announces today that the results from two different studies demonstrate catumaxomab’s capacity to activate the immune system in a way that can otherwise only be achieved through vaccination. The data were obtained by two independent research teams using catumaxomab in malignant ascites and gastric cancer, respectively. The results were recently presented at the annual meeting of the American Society of Clinical Oncology (ASCO).
In about half of the analyzed malignant ascites patients and the majority of gastric cancer patients, a significant increase of antibodies against tumor antigens was observed following the intraperitoneal administration of catumaxomab. In both studies, the antibody response was not restricted to catumaxomab’s target antigen EpCAM, but also included further cancer antigens suggesting the induction of a comprehensive humoral immune response against the individual tumor. Three of four patients who received a second treatment cycle showed an even stronger immune effect, comparable to the booster reaction known from repeated vaccination. In the gastric cancer study, cellular immune response was also analyzed and confirmed. The population of EpCAM-specific peripheral T cells was found to be substantially expanded, four weeks following the treatment.
These new results confirm the drug’s unique capacity to trigger several immune response mechanisms at the same time. Catumaxomab not only induces direct tumor cell destruction – as was presented during last year’s ASCO – but also a long-term vaccination effect against the individual tumor.
“This vaccination effect could provide a decisive advantage over current mono- or bispecific antibody approaches: Permanent treatment with catumaxomab will not be needed” , says Horst Lindhofer, CEO of TRION Pharma. “If we are next able to align these data with clinical outcome, this offers a paradigm shift in antibody-based cancer therapy: From chronic treatment to short-term application with long-term effects. This would lead to significant benefits, not only for cancer patients, but also for public healthcare systems.”
Catumaxomab is marketed by TRION Pharma’s partner Fresenius Biotech for the intraperitoneal treatment of malignant ascites. It is the most advanced representative of TRION Pharma’s unique family of Triomab® antibodies and presently the only approved trifunctional, bispecific antibody on the market world-wide. Three more Triomab® candidates are currently under preclinical or clinical development for the treatment of various cancers.
Triomab®: Trifunctional antibodies
TRION Pharma GmbH is a biopharmaceutical company developing trifunctional antibodies (Triomab®). The trifunctional antibodies are produced at TRION’s site in
Dr Dirk Pelster
TRION Pharma GmbH