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New Study Presented at Alzheimer’s Association International Conference 2017 (AAIC) Validates Equivalency of Pen-and-Paper Cognitive Assessment (SAGE) with its Digital Counterpart (eSAGE) to Detect Mild Cognitive Impairment and Early Dementias

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Monday, 17 July 2017 09:00 (UTC + 2)

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Widespread availability of self-administered eSAGE (BrainTest® https://braintest.com) expected to be a major factor in overcoming the many obstacles in identifying early cognitive impairment

London, UK, July 17, 2017 / B3C newswire / --BrainTest Inc., a medical software company that provides scientifically validated cognitive screening instruments on a wide range of tablets and mobile devices, today announced that the results of its Validity/Equivalency Study  were presented at the Alzheimer’s Association International Conference 2017 (AAIC).

Data presented by Dr. Douglas W. Scharre, Professor of Clinical Neurology and Psychiatry at The Ohio State University Wexner Medical Center demonstrates eSAGE performs similarly with neuropsychological batteries, MoCA, and MMSE and shows no scale bias compared to the validated SAGE. Meaning eSAGE has a high sensitivity (71%)  and specificity (90%) in detecting cognitive impairment from normal subjects, with the added advantage of private at-home self-administration.  Dr. Scharre’s results and data presentation will be available for the remainder of the AAIC at Location S8, P1-304.

Results of eSAGE Validity/Equivalency Study
Of the 426 subjects screened, 66 completed the evaluation. eSAGE score correlation to a battery of neuropsychological tests was 0.73 (p < 0.0001) with no significant difference between the paper and digital format. Spearman correlation of SAGE versus eSAGE was 0.88 (p < 0.0001), and they are related by the formula: eSAGE score = –1.05 + 0.99 × SAGE score. Since the slope is very close to 1 (p = 0.86) there is strong evidence that the scaling is identical between eSAGE and SAGE, with no scale bias. Overall, eSAGE scores are lower by an average of 1.21 and the decrease is statistically significant (p < 0.0001). For those subjects familiar with smartphones or tablets (one measure of digital proficiency), eSAGE scores are lower by an average of 0.83 points (p = 0.029). With a score 16 and higher being classified as normal, eSAGE had 90% specificity and 71% sensitivity in detecting those with cognitive impairment from normal subjects.

Design of eSAGE Validity/Equivalency Study
Over an 18 month period subjects aged 50 and over who had taken SAGE were recruited from community and clinic settings. Subjects were randomly selected to participate in a clinical evaluation including neuropsychological evaluations. SAGE and eSAGE were administered using a crossover design. Subjects were identified as dementia, MCI, or normal based on standard clinical criteria. Associations were investigated using Spearman correlations, linear regression, and sensitivity and specificity measures. The results of the study were recently published in Alzheimer’s Research & Therapy. For more information visit: https://alzres.biomedcentral.com/articles/10.1186/s13195-017-0269-3

About SAGE Test
The Self-administered Gerocognitive Examination (SAGE) is a brief cognitive assessment for mild cognitive impairment (MCI) and early dementia, created by Dr. Douglas Scharre, Professor of Clinical Neurology and Psychiatry at The Ohio State Wexner Medical Center in Columbus, Ohio. It was validated in the setting of mild cognitive impairment, and has subsequently been adopted in numerous other settings clinically. SAGE has the advantage of self-administration, brevity, and 4 interchangeable forms to avoid retest and practice biases.

About BrainTest Inc.
BrainTest is a medical software company that provides scientifically validated cognitive screening instruments on a wide range of tablets and mobile devices. The company empowers patients to monitor their cognition and learn objective evidence-based recommendations about their brain health in the comfort and privacy of their own homes. Through its partnership with The Ohio State University, BrainTest holds the exclusive digital rights to the Self-Administered Gerocognitive Examination (SAGE Test).


Michael Kader
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