Team SDR

  1. Home
  2. Research Teams
  3. Oncology
  4. Team SDR

Oncology

Team SDR

Synthetic Lethality in DNA Repair

The group aims to translate new synthetic lethal interactions between DNA repair genes into novel therapeutic targets in oncology. By performing targeted pooled screens in cells deficient in DNA repair genes, team SDR will strive to identify and characterize new drug targets in DNA repair and DNA replication as a potent tool to increase the efficiency of clinically used DNA damaging agents.

 Mentors
  • Dr. Balca Mardin
    Head of Laboratory, DNA Damage Response Research at Merck (Industry mentor)
  • Dr. Amir Abdollahi
    Translational Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg (Academic mentor)

Team Location BioMed X Institute Heidelberg

The research of this team is kindly sponsored by Merck.

Our Team Members

Dr. Özdemirhan Serçin

Group Leader

 Short Bio
  • 2016 – 2021: Postdoctoral Researcher, Team DDC, BioMed X Institute, Heidelberg, Germany
  • 2012 – 2015: Postdoctoral research fellow in the laboratory of Prof. Dr. Cedric Blanpain, IRIBHM, UniversitĂ© Libre de Bruxelles, Belgium
  • 2006 – 2011: PhD Student and research assistant in the laboratory of Prof. Dr. Aziz Sancar, Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, NC, USA
 Contact

Dr. Raktim Biswas

Postdoctoral Researcher

 Short Bio
  • 2018 – 2022: Postdoctoral Researcher, Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
  • 2015 – 2016: Postdoctoral Scholar, Department of Biology, University of Louisville, Kentucky, USA
  • 2012 – 2018: Postdoctoral Researcher, Beckman Laser Institute Korea, Cheonan, South Korea
  • 2007 – 2011: PhD in Molecular Biology, University of Kalyani, Kalyani, India
 Contact

Manisha Manojkumar Singh

Research Assistant

 Short Bio
  • 2017 – 2020: Master of Science in Molecular Biosciences, Major Cancer Biology, Heidelberg University and DKFZ, Germany
  • 2019: Internship at Broad Institute of MIT and Harvard, Boston, USA
  • 2012 – 2016: Bachelor of Engineering, BMSCE, Bangalore, India
 Contact

Finn Grözinger

Master's Student

 Short Bio
  • 2021 – ongoing: Master of Science in Molecular Biosciences, Majoring in Molecular and Cellular Biology, Heidelberg University, Germany
  • 2023: Visiting Graduate Student at the Dana-Farber Cancer Institute, Boston, USA
  • 2018 – 2021: Bachelor of Science in Biology, Goethe Universität Frankfurt, Frankfurt am Main, Germany
 Contact

Team SDR Alumni

At BioMed X we care for the people who work with us. Staying in touch with those who left but mainly contributed to BioMed X’s success is key. That’s why they have their designated place on our website. So let’s keep connected!

Yuliia Borysovych

 Contact
No contact information available.

Preeti Thiyagarajan

 Contact

Saheri Sikdar

 Contact

Amelia Kurti

 Contact

Berçin Yildiran

 Contact

Izlem Su Akan

 Contact

Seyedehsaba Nateghi

 Contact

Learn more about BioMed X

Team RSC

Team RSC

Splicing of mRNA is a crucial process in eukaryotic gene expression regulation, and aberrant splicing plays a critical role in the pathogenesis of several molecular subtypes of cancer. Such splicing abnormalities can lead to constitutive activity of oncogenes, reduced expression of tumor suppressors, or drug resistance. Our team is seeking to identify key molecular mechanisms that generate mRNA sp…

Read more

Team EDC

Team EDC

The objective of the group will be to investigate the formation, maintenance and consequences of extrachromosomal DNA (ecDNA) in cancer using cutting edge single-cell screening and spatial technologies.

Read more