Somatoprim Demonstrates Superior Side Effect Profile Over Octreotide
Tel Aviv, Israel, April 22, 2014 / B3C newswire / - Aspireo Pharmaceuticals Limited (“Aspireo”), an Israeli biopharmaceutical company, focused on the development of Somatoprim (DG3173), a novel somatostatin analog (SSA), today reported final data from a further phase Ib study in healthy volunteers.
In this single-dose, randomized, 5-way cross-over study, healthy volunteers were treated with the highest approved dose of octreotide, three different doses of Somatoprim (DG3173) and placebo control. The main purpose of the study was to investigate the effects of each treatment on the control of plasma glucose as well as the secretion of insulin and glucagon following a standard meal.
The final data demonstrate that octreotide significantly inhibits the secretion of insulin and glucagon in humans and shows a significant and sustained increase of plasma glucose levels.
In contrast, DG3173 has much less of an effect on insulin and glucagon release compared to octreotide, as well as the normalization of glucose control. This improved profile was observed even at high doses of DG3173.
Carsten Dehning, CEO of Aspireo Pharmaceuticals said: ”This study clearly demonstrates the superiority in the side effect profile of DG3173 over octreotide. These results confirm the findings from pre-clinical studies and support the unique profile of this promising investigational drug with respect to glycaemic control.”
Somatoprim (DG3173) is a novel and proprietary somatostatin analog (SSA) that is based on a novel amino acid composition. Somatoprim has demonstrated a unique receptor binding and pharmacological profile which is significantly differentiated from SSAs that are currently marketed or in clinical development. In particular, Somatoprim has shown an improved side effect profile with reduced adverse effects on the gastrointestinal tract and glucose metabolism. Furthermore, assessment of growth hormone secretion in cultured human somatotroph adenoma tissue treated with Somatoprim indicates that it has the potential to increase the response rate of acromegalic patients to SSA therapy. Somatoprim is currently in phase II of clinical development. Somatostatin analogs have been approved for the treatment of acromegaly, carcinoid tumors, and Cushing’s disease but have also demonstrated significant potential in diabetic retinopathy. Somatostatin analogs are generating more than USD 1.5 billion in annual sales in a continually growing market.
Aspireo Pharmaceuticals Ltd is a biopharmaceutical company focused on the development of a novel somatostatin analog (SSA) for the treatment of diseases resulting from hormone-active tumors, such as acromegaly, neuroendocrine and gastroenteropancreatic tumors, Cushing’s Disease and diabetic retinopathy. Aspireo’s sole development compound is Somatoprim (DG3173), a novel and proprietary somatostatin analog that is based on a novel amino acid composition and a unique backbone cyclization technology used for stabilization of the peptide. Aspireo is an Israeli company established in 2010 by TVM Capital as a Project Focused Company (PFC). For additional information please visit www.aspireopharma.com.
Chief Executive Officer
Aspireo Pharmaceuticals Limited
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