Bangalore, India, April 11, 2018 / B3C newswire / -- Aurigene will present data for its
- Proprietary novel, first-in-class, small molecule antagonists of CD47-SIRPα interaction program which is currently in late preclinical stage. Aurigene plans to file an IND by Q4 2018
- Preclinical stage, novel, selective PRMT5 inhibitors
- Lead optimization stage covalent, highly selective CDK12 inhibitors program and
- Selective, degrader of SMARCA2/4
Additional information on the presentations can be found below and abstracts can be accessed at www.aacr.org.
Additional details of our pipeline available for partnering can be found at: http://www.aurigene.com/proprietary-programs/
Poster Presentations
Small Molecule, Oral antagonists targeting CD47- SIRPα
Title: Combination efficacy and safety profile of an orally bioavailable small molecule agent targeting CD47/SIRPα axis
Session Category: Experimental and Molecular Therapeutics
Session Title: Novel and Canonical Targets
Session Date and Time: Tuesday Apr 17, 2018 8:00 AM - 12:00 PM
Location: McCormick Place South, Exhibit Hall A, Poster Section 35
Poster Board Number: 18
Permanent Abstract Number: 3852
Covalent, selective, CDK12 inhibitors
Title: Preclinical evaluation of PD and efficacy of novel potent selective and orally bioavailable CDK12 covalent inhibitors in TNBC model
Session Category: Molecular and Cellular Biology / Genetics
Session Title: Kinases and Phosphatases
Session Date and Time: Monday Apr 16, 2018 1:00 PM - 5:00 PM
Location: McCormick Place South, Exhibit Hall A, Poster Section 17
Poster Board Number: 21
Permanent Abstract Number: 2384
Selective PRMT5 inhibitors
Title: Preclinical In vivo evaluation of efficacy, pharmacokinetics and pharmacodynamics of novel PRMT5 inhibitors in multiple tumor models
Session Category: Molecular and Cellular Biology / Genetics
Session Title: Epigenetic Therapy
Session Date and Time: Monday Apr 16, 2018 8:00 AM - 12:00 PM
Location: McCormick Place South, Exhibit Hall A, Poster Section 16
Poster Board Number: 16
Permanent Abstract Number: 1392
SMARCA2/4 degraders
Title: Identification of SMARCA2/4 degraders for the treatment of SMARCA4-mutant and other cancers
Session Title: Late-Breaking Research: Experimental and Molecular Therapeutics 3
Session Date and Time: Tuesday Apr 17, 2018 1:00 PM - 5:00 PM
Session Location: McCormick Place South, Poster Section 43
Poster Board Number: 2
Permanent Abstract Number: LB-258
About Aurigene
Aurigene is a specialized biotechnology company, engaged in discovery and clinical development of novel and best-in-class therapies to treat cancer and inflammatory diseases. Aurigene is focused on oral check-point inhibitors, precision-oncology and the Th-17 pathway. Aurigene’s oral PD-L1/ VISTA antagonist program is currently in Phase 2 clinical development in India (trial initiated by Aurigene). Aurigene has filed an IND for its RORg program for autoimmune diseases and expects to initiate Phase I studies by Jun-2018. Aurigene has also developed selective CDK7 inhibitors with a likely IND by Q4 2018. Aurigene has partnered with several large- and mid-pharma companies in the United States and Europe and has delivered over 15 compounds which are in clinical development.
Contact
Rajshree KT
Director Strategic Alliances
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